I. Durak et al., Reduced antioxidant defense capacity in myocardial tissue from guinea pigstreated with 5-fluorouracil, J TOX E H A, 59(7), 2000, pp. 585-589
Citations number
29
Categorie Soggetti
Environment/Ecology,"Pharmacology & Toxicology
Journal title
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Antioxidant defense capacity was investigated in myocardial tissue from gui
nea pigs treated with 5-fluorouracil (5-FU) at a dose of 400 mg/kg/d daily
for 5 d administered intraperitonally. Treatment with 5-FU lowered the acti
vities of cardiac superoxide dismutase(SOD) and glutathione peroxidase (GSH
-Px) accompanied by higher catalase (CAT) activity. Further, antioxidant po
tential (AOP) values were lower but oxidation resistance (OR) and malondial
dehyde (MDA) levels were higher in the 5-FU-treated tissue. With regard to
myocardial iron (Fe) and copper (Cu) levels, no significant differences wer
e found between the groups. Results suggest that 5-FU treatment causes impa
irment in the myocardial antioxidant defense system and leads to cardiac pe
roxidation. It has been postulated that these changes might be responsible
for the 5-FU cardiotoxicity seen in some patients, and antioxidant therapy
might provide a therapeutic advantage.