A PROCEDURE FOR FEASIBLE AND OPTIMAL OPERATIONAL STRATEGIES FOR CONTROL OF CARE SYSTEMS

In Biochemical Engineering, the downstream stage to recover and purify product obtained from fermentation plays a central role in the commer cial success of the process. Previously, the continuous adsorption rec ycle extraction (CARE) process was optimized using experimental design and surface response analysis. Such an approach did not require the u se of reduced models. Thus, through a derailed model of the system and extensive simulation, operational restrictions, the whole set of proc ess variables and design details in the analysis were accounted for. T hrough this procedure, a new optimal set-point was applied to the cont rol algorithm developed to give higher system performance. The appropr iate manipulated variable was determined from the dynamic responses an d control strategies could be defined. The classical proportional inte gral (PI) and proportional integral derivative (PID) feedback and non- conventional feedback-feedforward controllers were studied. The result s show that the performance was good even with time delays up to 24 an d 36 min, respectively.