Br. Davidson et al., Results of choledochojejunostomy in the treatment of biliary complicationsafter liver transplantation in the era of nonsurgical therapies, LIVER TRANS, 6(2), 2000, pp. 201-206
Advances in radiological and endoscopic techniques have allowed many biliar
y complications after orthotopic liver transplantation (OLT) to be managed
without surgery. The influence of nonsurgical management on the outcome of
patients requiring surgical revision has not been addressed. We reviewed ou
r 10-year experience (October 1988 to January 1998) of Roux-en-Y choledocho
jejunostomy (CDJ) to treat biliary complications after OLT. Forty-six patie
nts underwent CDJ for biliary complications (32 men, 14 women; age, 22 to 6
5 years; median, 60 years). Biliary reconstruction at the time of OLT was d
uct to duct in 41 patients, primary CDJ in 3 patients, and gall bladder con
duit in 2 patients. T-tubes were used only in patients with gallbladder con
duit. The indication for CDJ was biliary leak (23 patients), stricture (20
patients), biliary stones (2 patients), and biliary sludge (1 patient). Two
patients (4.3%) had associated hepatic artery thrombosis. The bile leaks w
ere diagnosed at a median of 29 days post-OLT (range, 2 to 65 days) and str
ictures at a median of 2 years (range, 33 days to 6.5 years) post-OLT. Befo
re surgery, 25 patients (54%) underwent an attempt at radiological or endos
copic therapeutic intervention that failed, Median follow-up was 5 years (r
ange, 9 months to 10 years), Early complications occurred in 12 patients (2
6%); the most common was chest infection (4 patients). There were 3 periope
rative deaths (6%); 1 death was directly related to surgery. Late complicat
ions, mainly anastomotic strictures, occurred in 10 patients (22%), half of
which were successfully treated by biliary balloon dilatation. The complic
ation rate post-CDJ was less in those who underwent a failed nonsurgical ap
proach than those proceeding straight to surgery (3 of 25 patients; 36% v 1
3 of 21 patients; 62%; P =.21, not significant). The procedure-related mort
ality for surgical revision of biliary complications after OLT is low, but
early and late complications are common. A failed attempt at nonsurgical ma
nagement does not increase the complications of reconstructive surgery. Str
ictures after CDJ should be considered for biliary balloon dilatation. Copy
right (C) 2000 by the American Association fbr the Study of Liver Diseases.