Spatial and temporal evolution of hemorrhage in the hyperacute phase of experimental spinal cord injury: In vivo magnetic resonance imaging

Citation
M. Bilgen et al., Spatial and temporal evolution of hemorrhage in the hyperacute phase of experimental spinal cord injury: In vivo magnetic resonance imaging, MAGN RES M, 43(4), 2000, pp. 594-600
Citations number
43
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
MAGNETIC RESONANCE IN MEDICINE
ISSN journal
07403194 → ACNP
Volume
43
Issue
4
Year of publication
2000
Pages
594 - 600
Database
ISI
SICI code
0740-3194(200004)43:4<594:SATEOH>2.0.ZU;2-M
Abstract
To follow the spatial and temporal evolution of hemorrhage, in vivo MRI stu dies of experimental spinal cord injury (SCI) were performed on 17 rats in the very acute phase (hyperacute), starting as early as 9 min and continued up to 400 min posttrauma. Axial MR images were processed slice by slice ov er a 21 mm length around the epicenter of the injury. The data were analyze d statistically and fitted to an empirically derived function to characteri ze the spatial and temporal evolution of hemorrhage. The results indicated that 1) the initial hemorrhage in the very early phase of the injury area c overed 12.5% of the total cord area and subsequently increased with a time constant of 700 min, 2) a major portion of the hemorrhage was concentrated spatially within the 4 mm distance from the epicenter, 3) the volume of hem orrhage normalized to its initial value increased linearly at a rate of app roximately 0.0015 min(-1), and 4) edema was observed at the gray- and white -matter junction as early as 12 min postinjury, In general, edema appeared to be focal and scattered in this phase of the injury, which made its quant ification unreliable on MRI. (C) 2000 Wiley-Liss, Inc.