The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family

Authors
Sivasankaran, R Calleja, M Morata, G Basler, K
Citation
R. Sivasankaran et al., The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family, MECH DEVEL, 91(1-2), 2000, pp. 427-431
Citations number
14
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
91
Issue
1-2
Year of publication
2000
Pages
427 - 431
Database
ISI
SICI code
0925-4773(20000301)91:1-2<427:TWTGDE>2.0.ZU;2-W
Abstract
Here we report the identification of Dfz3, a novel member of the Frizzled f amily of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target ge ne of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated ra ther than repressed by Wg signalling in imaginal discs. We show that DFz3 i s not required for viability but is necessary for optimal Wg signalling at the wing margin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved .