Changes in psychic and somatic well-being and cognitive capabilities of peri- and postmenopausal women after the use of a hormone replacement drug containing estradiol valerate and levonorgestrel

A multicenter, prospective, open-label postmarketing surveillance study exa mined to what extent 2-month oral hormone replacement therapy (estradiol va lerate and levonorgestrel; Klimonorm(R)) could produce changes in psychosom atic well-being, self esteem and cognitive capabilities in 78 peri- and pos tmenopausal women. The women included were 42-58 years of age and had appro ached the physician due to climacteric symptoms. The following tests were u sed: Kupperman index, Menopause Rating Scale (MRS II), General Depression S cale (ADS), Zerssen's Symptom List (B-L), Frankfurt Self-Concept Scales (FS AL, FSAP, FSEG, FSSW), Digit Symbol Substitution Test (DSST), d2 Test of At tention and Number Square Test. The results showed a clear improvement in s ubjective psychosomatic well-being and improvements to a lesser extent in t he concentration and cognitive capabilities in women in the third treatment cycle. (C) 2000 Prous Science. All rights reserved.