Toll-like receptors

Toll-like receptors (TLRs) are a growing family of molecules involved in in nate immunity. Accumulating evidence suggests that TLR molecules are involv ed in signalling receptor complexes which recognise components of Gram-posi tive and Gram-negative bacteria and mycobacteria. Differential expression a nd regulation as well as distinct though overlapping ligand recognition pat terns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robu st. (C) 2000 Editions scientifiques et medicales Elsevier SAS.