CR3: a general purpose adhesion-recognition receptor essential for innate immunity

Authors
Ehlers, MRW
Citation
Mrw. Ehlers, CR3: a general purpose adhesion-recognition receptor essential for innate immunity, MICROBES IN, 2(3), 2000, pp. 289-294
Citations number
45
Categorie Soggetti
Immunology
Journal title
MICROBES AND INFECTION
ISSN journal
12864579 → ACNP
Volume
2
Issue
3
Year of publication
2000
Pages
289 - 294
Database
ISI
SICI code
1286-4579(200003)2:3<289:CAGPAR>2.0.ZU;2-2
Abstract
CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobia l defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndro me in humans and the CD11b knockout mouse. CR3 is a highly versatile patter n-recognition receptor that activates leukocytes via signaling complexes an d actin reorganization, mediates phagocytosis, and promotes leukocyte trans migration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.