Stereo- and regio-control of 1,3-dipolar cycloaddition reactions by the aid of Lewis acid catalysts - Nitrone and aci-nitro compound cycloadditions

Much attention is now focussed on the stereo- and regiocontrol of 1,3-dipol ar cycloaddition reactions by the aid of a Lewis acid catalyst. The report of catalyzed asymmetric nitrone cycloadditions has triggered the accelerati on of research development of this field. This review describes the Lewis a cid-catalyzed nitrone cycloadditions to electron-deficient alkenes, the Lew is acid-catalyzed nitrone cycloadditions to electron-rich alkenes such as a llylic alcohols, and asymmetric nitrone and aci-nitro compound cycloadditio ns to electron-deficient alkenes catalyzed by DBFOX/Ph metal complexes.