Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis - A phase II pilot study

N-Chlorotaurine (NCT) is an endogenous microbicidal oxidant, This open pilo t study (phase IIa) with 9 patients was done to gain first knowledge on the tolerance of NCT in infectious conjunctivitis, By application of 1% NCT 5 times a day, no adverse effects could be observed, All 6 subjects with bact erial conjunctivitis were cured within 3-5 days, Two subjects with epidemic keratoconjunctivitis were treated for 7-10 days and 1 subject with herpes simplex blepharitis for 3 days with no rapid improvement but probable mitig ation of inflammation, Therefore, NCT seems to be useful in the treatment o f infectious conjunctivitis, and further investigation on its therapeutic e fficacy is suggested, Copyright (C) 2000 S. Karger AG,Basel.