Synthesis of trans-2-(1-aryl-1-methylethyl)cyclohexylamines

Authors
Lee, WY Salvador, JM Bodige, K
Citation
Wy. Lee et al., Synthesis of trans-2-(1-aryl-1-methylethyl)cyclohexylamines, ORG LETT, 2(7), 2000, pp. 931-932
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
7
Year of publication
2000
Pages
931 - 932
Database
ISI
SICI code
1523-7060(20000406)2:7<931:SOT>2.0.ZU;2-2
Abstract
[GRAPHICS] As a first example of opening a secondary aziridine with a tertiary carbani on, the title amines (3a-c, aryl = phenyl, 4-tert-butylphenyl, 2-naphthyl) were synthesized by opening N-(diphenylphosphinoyl)-7-azabicyclo[4.1.0]hept ane, aziridine 1, with the corresponding alpha-potassium isopropylarenes, f ollowed by hydrolysis of the resulting phosphinamides 2a-c.