Total synthesis of (-)-amphidinolide P

Authors
Williams, DR Myers, BJ Mi, L
Citation
Dr. Williams et al., Total synthesis of (-)-amphidinolide P, ORG LETT, 2(7), 2000, pp. 945-948
Citations number
51
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
7
Year of publication
2000
Pages
945 - 948
Database
ISI
SICI code
1523-7060(20000406)2:7<945:TSO(P>2.0.ZU;2-Y
Abstract
[GRAPHICS] The convergent enantiocontrolled total synthesis of the 15-membered macrola ctone (-)-amphidinolide P is reported. Key transformations include a Sakura i allylation, a Stille coupling for the formation of a fully functionalized acyclic precursor, and intramolecular transesterification.