Citation
K. Nakayama et al., Synthesis and antifungal activity of rhodopeptin analogues. 2. Modification of the west amino acid moiety, ORG LETT, 2(7), 2000, pp. 977-980
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060
→ ACNP
Volume
2
Issue
7
Year of publication
2000
Pages
977 - 980
Database
ISI
SICI code
1523-7060(20000406)2:7<977:SAAAOR>2.0.ZU;2-V
Abstract
[GRAPHICS]
Structure-activity relationships of the west amino acid modified analogues
of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus sp
ecies Mer-N1033, have been investigated, Among the analogues synthesized, 2
,2-difluoro and 2-hydroxy derivatives retained the antifungal activity with
better physical properties, i.e., solubility or acute toxicity.