A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents
Ej. Martinez et Ej. Corey, A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents, ORG LETT, 2(7), 2000, pp. 993-996
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An efficient process is described for the synthesis of 5, a key intermediat
e for the synthesis of the potent antitumor agents ecteinascidin 743 (1) an
d phthaiascidin (2) from the readily available building blocks 3b and 4.