Predictors for heparin resistance in patients undergoing coronary artery bypass grafting

Heparin resistance (HR) is a common event in cardiac operations. At present , no clear recognition of the risk factors for HR has been reached. The aim of this study was to determine a predictive model for HR, based on the pre operative patient's profile. Two hundred consecutive patients scheduled for elective coronary artery bypass operations were enrolled in a prospective trial. Demographics, type of preoperative anticoagulation therapy and preop erative coagulation profile were collected and statistically analysed with respect to the evidence of a HR. Heparin resistance was defined as at least one activated clotting time < 400 s after heparinization and/or the need f or purified antithrombin III (AT-III) administration. With a multivariate a nalysis we could identify five predictors for HR: AT-III less than or equal to 60%; preoperative subcutaneous heparin therapy; intravenous heparin the rapy; platelet count greater than or equal to 300 000 cells/mm(3); age grea ter than or equal to 65 years. We conclude that HR is a predictable event. In the presence of all the risk factors, the likelihood of HR is 99%; in th e absence of ail of them, it is 10%. Predicting HR allows us to apply many possible therapeutic strategies.