J. Gallinat et al., The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression, PSYCHOPHAR, 148(4), 2000, pp. 404-411
Rationale A serotonergic dysfunction is supposed to play a pathogenetic rol
e in depression, but there is it considerable number of non-responders in t
he acute treatment of depression with serotonergic agents like SSRI. Thus,
an indicator of central serotonergic activity could lead to a more specific
pharmacological treatment of depression. In animal and human data there is
a growing amount of evidence that a strong loudness dependency of late aud
itory evoked potentials (LDAEP) is an indicator of low serotonergic activit
y and vice versa. Objective: In 29 depressive inpatients (DSM-LII-R diagnos
is 296.x in 28 patients, 300.4 in one patient), the hypothesis was tested t
hat a strong LDAEP prior to treatment can predict a better clinical outcome
under SSRI treatment over 4 weeks. Results: Patients with a strong pre-tre
atment LDAEP had a significantly greater decrease of depressive symptoms (H
amilton Scale for Depression) after 4 weeks than patients with a flat LDAEP
. Significantly more responders fell into the group with a high LDAEP. Cont
rary to what might be expected, a second recording in a subsample of 19 pat
ients after 4 weeks of treatment failed to show changes in the LDAEP. Concl
usion: Our finding confirms the hypothesis, that a strong LDAEP, indicating
a low serotonergic activity, is related to a favorable response to acute S
SRI treatment ill depression. The LDAEP is a promising tool for the predict
ion of response to serotonin agonists in depression and it seems to be of c
linical importance.