A. Turler et al., Local treatment of hepatic metastases with low-level direct electric current: Experimental results, SC J GASTR, 35(3), 2000, pp. 322-328
Background: Several authors have recently reported encouraging results from
low-level direct current therapy in easily accessible malignant tumors. Ho
wever, antitumoral effects in colorectal metastases have not been investiga
ted experimentally. Methods: Using an animal model with induced hepatic met
astases. we analyzed the effectiveness and the tumor growth dynamics after
direct current application. Three weeks after induction tumor volumes were
estimated with magnetic resonance imaging (MRI). Then direct current (80 C/
cm(3)) was applied in the treatment group by means of one anode in the tumo
r center and four cathodes peripherally. In the control group electrodes we
re placed without applying current. Tumor growth dynamics was analyzed with
MRI after 3 and 5 weeks. After this all animals were killed, and the liver
s histologically examined. Results: After 5 weeks MRI showed a 1.6-fold tum
or enlargement in the treatment group versus a 2.9-fold enlargement in the
control group (Student t test, P = 0.0051). The histopathologic analysis of
the treated livers yielded a 21% complete response rate and a 78% partial
response rate. No necroses were found in the control group. Conclusions: Th
ese results confirm the effectiveness of low-level direct current applicati
on as a potential modality for the treatment of hepatic metastases.