Resolution of the flumequine intermediate 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Authors
Balint, J Egri, G Vass, G Schindler, J Gajary, A Friesz, A Fogassy, E
Citation
J. Balint et al., Resolution of the flumequine intermediate 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline, TETRAHEDR-A, 11(3), 2000, pp. 809-813
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
3
Year of publication
2000
Pages
809 - 813
Database
ISI
SICI code
0957-4166(200002)11:3<809:ROTFI6>2.0.ZU;2-U
Abstract
Racemic 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved b y the N-phthaloyl derivative of the (R)-enantiomer. The enantiomeric mixtur e was very effectively enriched by recrystallisation from either the melt ( working best for mixtures of relatively high starting enantiomeric purities ) or from solution of its hydrochloride salt (giving good results when appl ied for mixtures of moderate to medium enantiomeric purities). (C) 2000 Els evier Science Ltd, All rights reserved.