Electrochemical enzymatic deoxygenation of chiral sulfoxides utilizing DMSO reductase

Authors
Abo, M Dejima, M Asano, F Okubo, A Yamazaki, S
Citation
M. Abo et al., Electrochemical enzymatic deoxygenation of chiral sulfoxides utilizing DMSO reductase, TETRAHEDR-A, 11(3), 2000, pp. 823-828
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
3
Year of publication
2000
Pages
823 - 828
Database
ISI
SICI code
0957-4166(200002)11:3<823:EEDOCS>2.0.ZU;2-2
Abstract
Preparation of enantiomerically enriched sulfoxides by an electrochemical e nzymatic system utilizing DMSO reductase was studied. This system consists of a glassy carbon electrode as the working electrode, methyl viologen as t he mediator and DMSO reductase from Rhodobacter sphaeroides f. sp. denitrif icans as the catalyst. The (R)-enantiomers of chiral sulfoxides in the pres ence of a variety of functional groups were obtained with high e.e. (>97%) by this system. (C) 2000 Elsevier Science Ltd. All rights reserved.