Efficient kinetic resolution of (+/-)-4-methyl-Hajos-Parrish ketone by baker's yeast reduction

Authors
Hioki, H Hashimoto, T Kodama, M
Citation
H. Hioki et al., Efficient kinetic resolution of (+/-)-4-methyl-Hajos-Parrish ketone by baker's yeast reduction, TETRAHEDR-A, 11(3), 2000, pp. 829-834
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
3
Year of publication
2000
Pages
829 - 834
Database
ISI
SICI code
0957-4166(200002)11:3<829:EKRO(K>2.0.ZU;2-1
Abstract
Kinetic resolution of (+/-)-4-methyl-Hajos-Parrish ketone (+/-)-2a using ba ker's yeast reduction was investigated. The reaction rate and enantiomeric purity depended on the concentration of substrate and yeast. Under concentr ated conditions, (-)-2a and the alcohol (+)-3 were obtained in high enantio meric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.