Sv. Jacob et al., EXERCISE ABILITY IN SURVIVORS OF SEVERE BRONCHOPULMONARY DYSPLASIA, American journal of respiratory and critical care medicine, 155(6), 1997, pp. 1925-1929
Citations number
28
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
There is limited information concerning the exercise performance of lo
ng-term survivors of bronchopulmonary dysplasia (BPD), and much of wha
t is available pertains to those with relatively mild disease. The pre
sent study was undertaken to describe exercise responses in patients w
ith a history of severe BPD, defined as those patients with a clinical
and radiographic diagnosis of BPD who required supplemental oxygen at
least until they were 44 wk postconceptual age and who were discharge
d home on oxygen. Fifteen children with a history of severe BPD were m
atched for gestational age with 15 children who had previously had res
piratory distress syndrome but who did not develop BPD (Prem). These P
rem control children were subsequently compared with 13 healthy contro
l children born at term (Control) who were of similar postnatal age. P
articipants underwent pulmonary function testing, progressive exercise
testing on a cycle ergometer, and a steady-state exercise test with c
ardiac output determined by CO2-rebreathing. Despite the patients with
BPD having a lower FEV1 than those in the Prem group, who had lower v
alues than the Control group (BPD, 64 +/- 21%; Prem, 85 +/- 11%; Contr
ol, 95 +/- 8%), the exercise capacity did not differ between the BPD a
nd the Prem and between the Prem and the Control groups (BPD, 84 +/- 1
5%; Prem, 81 +/- 17%; Control, 91 +/- 12%). However, the BPD patients
used a greater percentage of their ventilatory reserve ((V) over dot E
max/40 FEV1: BPD, 93 +/- 20%; Prem, 67 +/- 12%; Control, 59 +/- 13%).
Of the four patients with BPD who had significant oxygen desaturation
with exercise, three had the lowest values for FEV1. Cardiac output wa
s appropriate for oxygen consumption in most patients.