Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.)

The effect of exposure to sublethal concentrations of the organophosphate p esticide, quinalphos (1.12, 0.22 mg/l) on biochemical parameters of muscle and enzyme activities in brain, liver and kidney of the Indian major carp, Labeo rohita was studied after 15, 30 and 45 days. The muscle protein and R NA levels decreased whereas DNA levels and acid phosphatase were elevated. Similarly, alkaline phosphatase was depleted. The brain acetyl cholinestera se activity was decreased most (- 75.43%) in 1.12 mg/l concentration over a period of 45 days. Lactic dehydrogenase levels in brain and liver were ele vated whereas in the kidney they were inhibited. Succinic dehydrogenase and adenosine triphosphatase activities were depleted in brain, liver and kidn ey. The effects have been discussed for different organ tissues in relation to the pesticide. (C) 2000 Elsevier Science Ireland Ltd. All rights reserv ed.