Effect of vitamin E on lipid peroxidation and liver monooxygenase activityin experimental influenza virus infection

Influenza virus infection was associated with development of oxidative stre ss in liver of mice, viz. increase in amount of lipid peroxidation products , decrease in cytochrome P-450 and NADPH-cytochrome c-reductase activity, a nd inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N -demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These e ffects were most pronounced on the 7th day after virus inoculation as compa red to the 5th one. Supplementation of mice with vitamin E before virus ino culation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochr ome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one. (C) 2000 Elsevier S cience Ireland Ltd. All rights reserved.