Pgm. Kienhuis et Rb. Geerdink, Liquid chromatography-tandem mass spectrometric analysis of surface and waste water with atmospheric pressure chemical ionisation - I: instrumentation, TRAC-TREND, 19(4), 2000, pp. 249-259
Liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS), i.e
. LC-MS/MS, is a technique for the analysis of medium polarity to ionic com
pounds. This and the following paper highlight the potential and limitation
s of atmospheric pressure chemical ionisation (APCI) combined with MS/MS in
the analysis of water. Part I describes the APCI interface and the scan mo
des of a triple quadrupole mass spectrometer. It gives a general introducti
on to the instrumentation, from a practical point of view. Part II gives mo
re detailed information, in which the instrumentation is optimised for and
used in the analysis of surface water and waste water. Attention is paid to
the use of methanol versus acetonitrile as organic modifier in combination
with APCI, the application of the RF-only daughter scan mode, and the quan
titation of known compounds and the identification of unknown compounds fou
nd in surface and waste water. (C) 2000 Elsevier Science B.V. All rights re
served.