A population is ''hidden'' when no sampling frame exists and public ac
knowledgment of membership in the population is potentially threatenin
g. Accessing such populations is difficult because standard probabilit
y sampling methods produce law response rates and responses that lack
candor. Existing procedures for sampling these populations, including
snowball and other chain-referral samples, the hey-informant approach,
and targeted sampling, introduce well-documented biases into their sa
mples. This paper introduces a new variant of chain-referral sampling,
respondent-driven sampling, that employs a dual system of structured
incentives to overcome some of the deficiencies of such samples. A the
oretic analysis, drawing on both Markov-chain theory and the theory of
biased networks, shows that this procedure can reduce the biases gene
rally associated with chain-referral methods. The analysis includes a
proof showing that even though sampling begins with an arbitrarily cho
sen set of initial subjects, as do most chain-referral samples, the co
mposition of the ultimate sample is wholly independent of those initia
l subjects. The analysis also includes a theoretic specification of th
e conditions under which the procedure yields unbiased samples. Empiri
cal results, based on surveys of 277 active drug injectors in Connecti
cut, support these conclusions. Finally, the conclusion discusses how
respondent-driven sampling can improve both network sampling and ethno
graphic 44investigation.