Tissue engineering of the bladder

Citation
G. Falke et al., Tissue engineering of the bladder, WORLD J URO, 18(1), 2000, pp. 36-43
Citations number
46
Categorie Soggetti
Urology & Nephrology
Journal title
WORLD JOURNAL OF UROLOGY
ISSN journal
07244983 → ACNP
Volume
18
Issue
1
Year of publication
2000
Pages
36 - 43
Database
ISI
SICI code
0724-4983(200002)18:1<36:TEOTB>2.0.ZU;2-0
Abstract
When gastrointestinal tissue is used for bladder augmentation or replacemen t, multiple complications may ensue, such as infection, metabolic disturban ces, urolithiasis, perforation, increased mucous production, and malignancy . Therefore, alternative methods are being sought for cystoplasty. There ha s been a resurgence of interest in the use of acellular collagen-based matr ices as scaffolds for bladder regeneration. Experimental work involving sev eral collagen matrices, such as allogenic bladder and intestinal tissues, i s currently being conducted in several academic centers. Recently, function al bladder tissue has been engineered using selective cell transplantation. The approach that has been followed for bioengineering of bladder tissue i nvolves the use of autologous cells, thus avoiding rejection. whereby a bio psy of tissue is obtained from the host. after which the cells are dissocia ted and expanded in vitro. reattached to a matrix, and implanted into the s ame host.