Influences of aceclofenac on thyroid hormone binding and thyroid function

Influences of non-steroidal anti-inflammatory drugs (NSALD)on concentration s of thyroid hormones are known for a long time. These effects could be exp lained with interference between NSAIDs and thyroid hormone binding. We inv estigated the effects of a single dose of aceclofenac on thyroid function a nd thyroid hormone binding in 18 healthy volunteers. Serum levels of free t hyroid hormones (FT3, FT4) and thyrotropin (TSH) were measured with commerc ial available kids and thyroid hormone binding was estimated with a special ly modified horizontal argarose-gel-electrophoresis prior to and 2 hours af ter receiving a single dose of aceclofenac. We found a significant decrease in T3 binding on TBG and a significant increase of albumine-bound T3. All other investigated thyroid hormone binding parameters, FT3 and FT4. showed no significant changes. We conclude that aceclofenac leads to a significant redistribution of T3 protein binding. These effects seem to be explained b y T3 displacement from TBG induced by aceclofenac.