Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission

Objective: To compare cognitive functioning in relation to white matter les ions in bipolar disorder in remission and schizophrenia. Method: Cognitive performance and the occurrence of white matter lesions on MRI images of the brain were assessed in 22 patients with bipolar disorder in remission, 22 patients with schizophrenia and 22 healthy volunteers. Results: Performance of tests of memory, speed and cognitive flexibility wa s significantly impaired in both patient groups. The frequency of white mat ter lesions did not differ significantly between the three groups. No diffe rences in cognitive performance were found between patients with white matt er lesions and patients without such lesions. Conclusion: White matter lesions apparently do not underlie cognitive defic its that are found in patients with bipolar disorder in remission and in pa tients with schizophrenia.