Pocket 4 in the HLA-DRB1 antigen-binding groove: an association with atopy

Background: Many studies have attempted to identify an association between HLA genes and atopy, given the role of HLA molecules in the regulation of t he immune response. In the case of house-dust mites, it is difficult to iin d an association with a particular HLA allele, due to the complexity of the allergen. The objective was to investigate whether HLA-DRB1 functional gro ups are better correlated with the atopic disease in our population than DR B1 alleles. Methods: The method was reanalysis of the HLA-DRB1 data of a previous case/ control study. Results: The "Dr" group was found to be associated with the atopic disease in our population. Conclusions: Grouping HLA-DRB1 alleles into functional categories may assis t in the search for predictive factors in relation to atopic disease.