Synthesis and antibacterial activity of some new non-proteinogenic amino acids containing thiazole residues

Some new thioamides and thiazoles have been synthesized using canavanine, S -cysteine, homo-S-cysteinesulfonamides and their N-omega- aminoethylated de rivatives as adducts in order to investigate the structure-antimicrobial ac tivity relationships. The compounds showed substantial antibacterial activi ty in vitro against various gram-positive (Staphylococcus aureus, Bacillus cereus etc.) and gram-negative (Escherichia coli, Proteus vulgaris etc.) ba cteria. These findings indicate that the presence of the thiazole residue i s an essential factor for the antibacterial effect.