M. Stanchev et al., Synthesis and antibacterial activity of some new non-proteinogenic amino acids containing thiazole residues, AMINO ACIDS, 18(2), 2000, pp. 177-191
Some new thioamides and thiazoles have been synthesized using canavanine, S
-cysteine, homo-S-cysteinesulfonamides and their N-omega- aminoethylated de
rivatives as adducts in order to investigate the structure-antimicrobial ac
tivity relationships. The compounds showed substantial antibacterial activi
ty in vitro against various gram-positive (Staphylococcus aureus, Bacillus
cereus etc.) and gram-negative (Escherichia coli, Proteus vulgaris etc.) ba
cteria. These findings indicate that the presence of the thiazole residue i
s an essential factor for the antibacterial effect.