Primary hepatic lymphoma of MALT-type

We report a case of a 50-year-old man with chronic viral hepatitis B presen ting with a primary hepatic lymphoma of mucosa-associated lymphoid tissue, revealed clinically by a pedicular nodal mass. The liver biopsy showed an a ctive chronic hepatitis and a dense portal lymphoid infiltrate with centroc yte-like cells inducing typical biliary lympho-epithelial lesions. The lymp hnode biopsy revealed a marginal zone lymphoma pattern. A monoclonal rearra ngement of the immunoglobulin heavy chain gene was detected in the lymph no de by polymerase chain reaction, This case of primary hepatic mucosa-associated lymphoid tissue lymphoma con firms that the liver also contains mucosa-associated lymphoid tissue, in wh ich low grade lymphoma can arise.