We report two cases of pararenal angiomyolipomas, in two middle-aged women
without tuberous sclerosis. Both tumors were made of muscular epithelioid c
ells without atypia, some of which were stained by HMB-45 antibody. The fib
rous stroma contained numerous thick-walled blood vessels but no adipose co
mponent. The ultrastructural examination revealed that muscular epithelioid
cells contained myofilaments and melanosomas. Because of their immunohisto
chemical and ultrastructural profiles, both tumors may be included in the f
amily of lesions composed of perivascular epithelioid cells (PEC). This tum
or type is considered as a particular variant of angiomyolipoma with predom
inant muscular epithelioid component. The immunohistochemical expression of
progesterone and estrogen receptors by both tumors may suggest their hormo
nodependent character.