Sclerosing epithelioid fibrosarcoma: a fibrosarcoma with a very long course

Sclerosing epithelioid fibrosarcoma is a rare and slowly growing variant of fibrosarcoma occurring in adults. Its carcinomatous and/or hemangiopericyt omatous patterns may mislead to many different tumors. These differential d iagnoses are generally ruled out by the clinical data, the morphology and t he immunohistochemical study. We report two typical cases of this fibrosarc oma and we highlight the different criterias which are indispensable to mak e the diagnosis. The very slow course of this disease goes along with a ver y low proliferative rate, but an accumulation of p53 by immunohistochemical is paradoxically always founds, even though this accumulation is more ofte n found in highly aggressive sarcomas.