A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson's disease

Authors
Morino, H Kawarai, T Izumi, Y Kazuta, T Oda, M Komure, O Udaka, F Kameyama, H Nakamura, S Kawakami, H
Citation
H. Morino et al., A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson's disease, ANN NEUROL, 47(4), 2000, pp. 528-531
Citations number
19
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
47
Issue
4
Year of publication
2000
Pages
528 - 531
Database
ISI
SICI code
0364-5134(200004)47:4<528:ASNPOD>2.0.ZU;2-V
Abstract
We identified two polymorphisms out of all coding regions of the dopamine t ransporter gene. One existed in exon 9 (1215A/G) and another in exon 15 (18 98T/C). The 1215G was significantly less frequent among patients with Parki nson's disease than the controls. Although the polymorphism caused no amino acid substitution, we concluded that it was associated with decreasing the susceptibility to Parkinson's disease through mechanisms other than the pr otein function of dopamine transporter.