Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization

Objective To assess the influence of preoperative portal vein embolization (PVE) on t he long-term outcome of liver resection for colorectal metastases. Summary Background Data Preoperative PVE of the liver induces hypertrophy of the remnant liver and increases the safety of hepatectomy. Methods Thirty patients underwent preoperative PVE and 88 patients did not before r esection of four or more liver segments. PVE was performed when the estimat ed rate of remnant functional liver parenchyma (ERRFLP) assessed by CT scan volumetry was less than 40%. Results PVE was feasible in all patients, There were no deaths, The complication ra te was 3%. The post-WE ERRFLP was significantly increased compared with the pre-WE value, Liver resection was performed after PVE in 19 patients (63%) , with surgical death and complication rates of 4% and 7% respectively. WE increased the number of resections of more than four segments by 19% (17/88 ), Actuarial survival rates after hepatectomy with or without previous WE w ere comparable: 81%, 67%, and 40% versus 88% 61%, and 38% at 1, 3, and 5 ye ars respectively. Conclusions PVE allows more patients with previously unresectable liver tumors to benef it from resection, Long-term survival is comparable to that after resection without PVE.