Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer - Long-term results

Objective To evaluate retrospectively the long-term results of an approach consisting of performing surgery in every patient in whom radical removal of all meta static disease was technically feasible. Summary Background Data The indications for surgical resection for liver metastases from colorectal cancer remain controversial. Several clinical risk factors have been repor ted to influence survival. Methods Between March 1980 and December 1997, 235 patients underwent hepatic resect ion for metastatic colorectal cancer. Survival rates and disease-free survi val as a function of clinical and pathologic determinants were examined ret rospectively with univariate and multivariate analyses. Results The overall 3-, 5-, 10-, and 15-year survival rates were 51%, 38%, 26%, and 24%, respectively. The stage of the primary tumor, lymph node metastasis, and multiple nodules were significantly associated with a poor prognosis in both univariate and multivariate analyses. Disease-free survival was signi ficantly influenced by lymph node metastasis, a short interval between trea tment of the primary and metastatic tumors, and a high preoperative level o f carcinoembryonic antigen. The 10-year survival rate of patients with four or more nodules (29%) was better than that of patients with two or three n odules (16%), and similar to that of patients with a solitary lesion (32%). Conclusions Surgical resection is useful for treating liver metastases from colorectal cancer. Although multiple metastases significantly impaired the prognosis, the life expectancy of patients with four or more nodules mandates removal.