Vca. Martins et G. Goissis, Nonstoichiometric hydroxyapatite-anionic collagen composite as support forthe double sustained release of gentamicin and norfloxacin/ciprofloxacin, ARTIF ORGAN, 24(3), 2000, pp. 224-230
This work studied the sustained release of ciprofloxacin or norfloxacin and
gentamicin from nonstoichiometric hydroxyapatite (nHA) and anionic collage
n composite. Within the first 24 and 48 h, the total antibiotic supply was
significantly higher than the minimal inhibitory concentration required for
the majority of the gram-negative bacteria. Although gentamicin was comple
tely released from the matrix after 48 h by a normal diffusion mechanism, c
iprofloxacin or norfloxacin release was characterized by a 2-phase release
mechanism due to binding to nHA by complexation with calcium ion. Under the
conditions studied, most of the norfloxacin or ciprofloxacin only will be
disposable due to bioresorption or dissociation of the complexes. In conclu
sion, due to its biocompatibility nHA-anionic collagen composite may be a c
onvenient support for the double sustained release of the antibiotics genta
micin and ciprofloxacin/norfloxacin for the control of bone infection while
promoting bone tissue growth.