Nonstoichiometric hydroxyapatite-anionic collagen composite as support forthe double sustained release of gentamicin and norfloxacin/ciprofloxacin

Citation
Vca. Martins et G. Goissis, Nonstoichiometric hydroxyapatite-anionic collagen composite as support forthe double sustained release of gentamicin and norfloxacin/ciprofloxacin, ARTIF ORGAN, 24(3), 2000, pp. 224-230
Citations number
28
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
ARTIFICIAL ORGANS
ISSN journal
0160564X → ACNP
Volume
24
Issue
3
Year of publication
2000
Pages
224 - 230
Database
ISI
SICI code
0160-564X(200003)24:3<224:NHCCAS>2.0.ZU;2-Y
Abstract
This work studied the sustained release of ciprofloxacin or norfloxacin and gentamicin from nonstoichiometric hydroxyapatite (nHA) and anionic collage n composite. Within the first 24 and 48 h, the total antibiotic supply was significantly higher than the minimal inhibitory concentration required for the majority of the gram-negative bacteria. Although gentamicin was comple tely released from the matrix after 48 h by a normal diffusion mechanism, c iprofloxacin or norfloxacin release was characterized by a 2-phase release mechanism due to binding to nHA by complexation with calcium ion. Under the conditions studied, most of the norfloxacin or ciprofloxacin only will be disposable due to bioresorption or dissociation of the complexes. In conclu sion, due to its biocompatibility nHA-anionic collagen composite may be a c onvenient support for the double sustained release of the antibiotics genta micin and ciprofloxacin/norfloxacin for the control of bone infection while promoting bone tissue growth.