DENTAL ABNORMALITIES IN CHILDREN TREATED FOR ACUTE LYMPHOBLASTIC-LEUKEMIA

The purpose of this study was to define the therapy-associated dental abnormalities in survivors of acute lymphoblastic leukemia (ALL). We r eviewed the clinical records and panoramic radiographs of 423 survivor s of ALL who were treated on one of four consecutive protocols (1975-1 991). Dental abnormalities included root stunting, microdontia, hypodo ntia, taurodontia (enlarged pulp chambers), and over-retention of prim ary teeth. The frequency of these factors was determined in relation t o age at initiation of treatment (less than or equal to 8 years vs >8 years), addition of cranial irradiation, and chemotherapeutic protocol . A total of 423 patients met the study criteria. The abnormalities co mprised root stunting in 24.4% (n = 103), microdontia in 18.9% (n = 80 ), hypodontia in 8.5% (n = 36), taurodontia in 5.9% (n = 25), and over -retention of primary dentition in 4.0% (n = 17). Patients who were le ss than or equal to 8 years old at diagnosis or who received cranial i rradiation therapy developed more dental abnormalities than did those >8 years and those who did not receive cranial irradiation (42 vs 32%) . Survivors of childhood ALL often have dental abnormalities that may affect their quality of life. Dental evaluation at diagnosis and frequ ent followup may help to ensure appropriate preventive measures and mi nimize dental and periodontal disease.