Inhibition of DNA topoisomerases by nidulalin A derivatives

Authors
Sato, S Fukuda, Y Nakagawa, R Tsuji, T Umemura, K Andoh, T
Citation
S. Sato et al., Inhibition of DNA topoisomerases by nidulalin A derivatives, BIOL PHAR B, 23(4), 2000, pp. 511-512
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
23
Issue
4
Year of publication
2000
Pages
511 - 512
Database
ISI
SICI code
0918-6158(200004)23:4<511:IODTBN>2.0.ZU;2-Z
Abstract
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II nith IC50 values of 2.2 m u M and 16 mu M, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 mu M.