A locus closely linked to Mtv7 on mouse chromosome 1 influences development of acute versus chronic graft-versus-host disease in a murine model

The relationship between acute and chronic graft-versus-host disease (GVHD) is not well understood. A murine model of acute and chronic GVHD is the B6 D2F1 parent --> F1 model in which transfer of C57BL/6 parental strain lymph oid cells to B6D2F1 recipients results in development of Th1-mediated acute GVHD, whereas transfer of DBA/2 parental strain lymphoid cells to B6D2F1 r ecipients results in development of Th2-mediated chronic GVHD. Numerous stu dies have investigated the reason for the differential development of acute versus chronic GVHD in this model but have as yet failed to identify the f actor that determines which type of T helper cell will predominate and ther eby which type of GVHD will develop. In this report, we demonstrate, using congenic strains of mice, that a locus in the vicinity of the Mtv7 locus on Chromosome 1 of the mouse significantly influences development of acute ve rsus chronic GVHD in the B6D2F1 model. (C) 2000 Academic Press.