Intra-abdominal hypertension (IAH) associated with organ dysfunction define
s the abdominal compartment syndrome (ACS). Elevated intra-abdominal pressu
re (IAP) adversely impacts pulmonary, cardiovascular, renal, splanchnic, mu
sculoskeletal/integumentary, and central nervous system physiology. The com
bination of IAH and disordered physiology results in a clinical syndrome wi
th significant morbidity and mortality. The onset of the ACS requires promp
t recognition and appropriately timed and staged intervention in order to o
ptimize outcome. The history, pathophysiology, clinical presentation, and m
anagement of this disorder is outlined.