Calcium pumps: structural basis for and mechanism of calcium transmembranetransport

Authors
Carafoli, E Brini, M
Citation
E. Carafoli et M. Brini, Calcium pumps: structural basis for and mechanism of calcium transmembranetransport, CURR OP C B, 4(2), 2000, pp. 152-161
Citations number
66
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
2
Year of publication
2000
Pages
152 - 161
Database
ISI
SICI code
1367-5931(200004)4:2<152:CPSBFA>2.0.ZU;2-U
Abstract
Eukaryotic cells remove calcium from the cytosol using P-type pumps in the plasma membrane and in the sarco(endo)plasmic reticulum. These pumps share membrane topography and general mechanism of action, but differ in regulato ry properties. Recent advances in the field include the three-dimensional s tructure of the sarco(endo)plasmic reticulum and further understanding of t he transcriptional regulation of the plasma membrane P-type pump by calcium .