Metal ions in ribozyme folding and catalysis

Authors
Hanna, R Doudna, JA
Citation
R. Hanna et Ja. Doudna, Metal ions in ribozyme folding and catalysis, CURR OP C B, 4(2), 2000, pp. 166-170
Citations number
34
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
2
Year of publication
2000
Pages
166 - 170
Database
ISI
SICI code
1367-5931(200004)4:2<166:MIIRFA>2.0.ZU;2-X
Abstract
Current research is reshaping basic theories regarding the roles of metal i ons in ribozyme function. No longer viewed as strict metalloenzymes, some r ibozymes can access alternative catalytic mechanisms depending on the ident ity and availability of metal ions. Similarly, reaction conditions can allo w different folding pathways to predominate, with divalent cations sometime s playing opposing roles.