Dimetallic hydrolases and their models

Authors
Kimura, E
Citation
E. Kimura, Dimetallic hydrolases and their models, CURR OP C B, 4(2), 2000, pp. 207-213
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
2
Year of publication
2000
Pages
207 - 213
Database
ISI
SICI code
1367-5931(200004)4:2<207:DHATM>2.0.ZU;2-7
Abstract
Recent mechanistic studies of Fe-3+/M2+ purple acid phosphatase present con flicting pictures about the roles of the metals. Recent model studies with Co3+/Co3+ and Fe3+/Fe3+ complexes have supported each conflicting mechanism for phosphate hydrolysis. With dizinc and trizinc complexes, the competiti ve binding of hydroxyl and phosphate substrates has been demonstrated.