Interleukin 7 is a potent Co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis

Citation
Bf. Bebo et al., Interleukin 7 is a potent Co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis, CYTOKINE, 12(4), 2000, pp. 324-331
Citations number
44
Categorie Soggetti
Cell & Developmental Biology
Journal title
CYTOKINE
ISSN journal
10434666 → ACNP
Volume
12
Issue
4
Year of publication
2000
Pages
324 - 331
Database
ISI
SICI code
1043-4666(200004)12:4<324:I7IAPC>2.0.ZU;2-A
Abstract
Interleukin 7 (IL-7), originally described as a B cell growth factor, has r ecently been found to play a critical role in T and B lymphocyte developmen t and function. This study evaluated the effects of IL-7 on myelin specific T cells. IL-7 strongly enhanced proliferation of proteolipid protein (PLP) 139-151 specific T cells in association with elevated secretion of the T c ell growth factor IL-2. Co-stimulation with IL-7 preferentially increased t he levels of pro-inflammatory cytokines secreted by PLP 139-151 specific T cells and adoptive transfer of these cells into naive recipients induced a profound enhancement of experimental autoimmune encephalomyelitis, an anima l model for the human disease multiple sclerosis, These results suggest tha t IL-7 may be a critical co-stimulatory. factor that enhances the extrathym ic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders. (C) 2000 Aca demic Press.