We assessed the effect of rIL-12 on the expression of class II molecules an
d on the ratio between SDS-stable and unstable ap dimers in dendritic cells
. We found that in vitro exposure of the cells to IL-12 increased their sur
face expression of mature class II molecules, despite a marked decline in c
lass II biosynthesis. This effect was accompanied by a striking increase in
the overall proportion of SDS-stable heterodimers. (C) 2000 Academic Press
.