Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999

Citation
Dp. Lovell et al., Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999, ENV MOL MUT, 35(3), 2000, pp. 260-263
Citations number
7
Categorie Soggetti
Molecular Biology & Genetics
Journal title
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
ISSN journal
08936692 → ACNP
Volume
35
Issue
3
Year of publication
2000
Pages
260 - 263
Database
ISI
SICI code
0893-6692(2000)35:3<260:RASOTM>2.0.ZU;2-C
Abstract
A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of ge noXtoxicity test procedures. Issues discussed included methods for integrat ing biological importance and statistical significance, the relationship of the experimental unit to the experimental design, and the impact of new de velopments in statistics and computing. Three major recommendations were ma de relating to the need for: (1) the effective use of statistical advice in designing interlaboratory and statistical advice in designing interlaborat ory and of appropriate experimental designs for new assays; and (3) educati on and training in the use of statistical methodology in mutagenicity testi ng. Published 2000 Wiley-Liss, Inc.