Kainate-induced neuronal injury leads to persistent phosphorylation of cAMP response element-binding protein in glial and endothelial cells in the hippocampus

Citation
Wy. Ong et al., Kainate-induced neuronal injury leads to persistent phosphorylation of cAMP response element-binding protein in glial and endothelial cells in the hippocampus, EXP BRAIN R, 131(2), 2000, pp. 178-186
Citations number
37
Categorie Soggetti
Neurosciences & Behavoir
Journal title
EXPERIMENTAL BRAIN RESEARCH
ISSN journal
00144819 → ACNP
Volume
131
Issue
2
Year of publication
2000
Pages
178 - 186
Database
ISI
SICI code
0014-4819(200003)131:2<178:KNILTP>2.0.ZU;2-B
Abstract
Intracerebroventricular kainate treatment in rats induces neuronal cell dea th, followed by proliferation and hypertrophy of glial cells in the lesione d area. To further understand the activated signal transduction pathways an d to get insights into potential target gene activation, the present study aims to elucidate lone-term effects on the phosphorylation state of cAMP re sponse element-binding protein (CREB) in the hippocampal formation. One to four weeks after kainate injection, we found high levels of phosphorylated and hence activated CREB (pCREB) in glial cells of the degenerating CA fiel ds. As shown by electron microscopy, pCREB immunoreactivity was present in reactive astrocytes, oligodendrocyte precursor cells and endothelial cells of blood vessels. It is postulated that pCREB could drive the expression of downstream genes in these cells to promote cell proliferation and survival .