Quinoxaline chemistry. Part 13: 3-carboxy-2-benzylamino substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-L-glutamates: synthesis and evaluation of in vitro anticancer activity

Among a new series of 28 3-carboxy or carbethoxy quinoxalines bearing a sub stituted benzylamino or N-[4-(aminomethyl)benzoyl]glutamate group on positi on 2 of the ring and various substituents at C-6, 7 positions, 21 were sele cted at the National Cancer Institute for evaluation of their in vitro anti cancer activity. The results obtained seem to confirm that the carboxy or c arbethoxy group on position 3 is not helpful, with a few exceptions, for th e anticancer activity. (C) 2000 Elsevier Science S.A. All rights reserved.