Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles

Authors
Mazzei, M Dondero, R Ledda, B Demontis, F Vargiu, L
Citation
M. Mazzei et al., Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles, FARMACO, 55(2), 2000, pp. 119-124
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
55
Issue
2
Year of publication
2000
Pages
119 - 124
Database
ISI
SICI code
0014-827X(200002)55:2<119:D3>2.0.ZU;2-I
Abstract
Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles posses sing a compact structure were active against HRV-2 and, consequently, prese nted a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synth esized in view to attempt type A activity against HRV-14. Unfortunately, al l tested compounds were devoid of activity against HRV-14 (and HIV-1) of ex hibited great toxicity. (C) 2000 Elsevier Science S.A. All rights reserved.